2-Bromo-1-phenyl-1-pentanone CAS 49851-31-2 Bromovalerophenone )
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1-Pentanone, 2-bromo-1-phenyl-
2-Bromo-1-phenylpentan-1-one
2-Bromo-1-phenyl-pentan-1-one
2-Bromo-1-phenyl-1-pentanone
2-Bromovalerophenone
α-Bromovalerophenone
2-Bromo-1-phenyl-1-pentanone
2Bromo1phenyl1pentanone
What is cas 49851-31-2, 2-Bromo-1-phenyl-1-pentanone , 2-Bromo-1-phenyl-1-pentanone ?
Also known as cas 49851-31-2 α-bromovalerophenone, α-Bromovalerophenone Cas 49851-31-2, Cas 49851-31-2 2-Bromovalerophenone . It is an organic intermediate obtained by bromination of sodium bromide with pentanone as raw material. It has been reported in the literature to be used in the preparation of histone demethylase inhibitors. CAS number is 49851-31-2, molecular formula is C11H13BrO , molecular weight is 241.12400, the following can be a brief information about 2-Bromo-1-phenyl-1-pentanone
How to prepare 2-Bromo-1-phenyl-1-pentanone Cas 49851-31-2?
At room temperature, add 16.2g (0.1mol) of pentanone and 30.9g (0.3mol) of sodium bromide to a 500mL round bottom flask. After stirring well, add 24 g (0.2 mol) of 30% hydrochloric acid and add slowly dropwise. Add 19g (0.15mol) 30% hydrogen peroxide. Continue the reaction for 1~2h after dropping. After monitoring the reaction by TLC, stop stirring, leave to stratify, wash with saturated sodium carbonate and saturated salt water, and combine the organic phases. Concentrate and dry with anhydrous magnesium sulfate to obtain 2-bromo-1-phenyl-1-pentanone as bright yellow oily liquid with 95% yield and 98% purity (HPLC method).
2-Bromo-1-phenyl-1-pentanone is an organic intermediate that can be obtained by sodium bromide bromination from phenylpentanone as raw material
2-Bromo-1-phenyl-1-pentanone can be used to prepare substituted imidazole derivatives with the following structure, which have efficient KDM1A enzyme inhibitory activity and selectivity over monoamine oxidase (MAO) for the prevention or treatment of diseases and conditions related to histone demethylase activity.
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At room temperature, add 16.2g (0.1mol) of phenylpentanone and 30.9g (0.3mol) of sodium bromide respectively in a 500mL round bottom flask, stir well, add 24g (0.2mol) of 30% hydrochloric acid, and slowly add 19g (0.15mol) of 30% hydrogen peroxide dropwise, after adding the junction Chemicalbook bundle dropwise, continue the reaction for 1~ 2h, TLC monitor the end of the reaction, stop stirring, resting stratification, washed with saturated sodium carbonate and saturated salt water, respectively, combined organic phase, concentrated and dried by anhydrous magnesium sulfate to obtain 2-bromo-1-phenyl-1-pentanone, bright yellow oily liquid, yield 95%, purity 98% (HPLC method).
